Short communication DISCRIMINATIVE STIMULUS EFFECTS OF MONOHYDROXYLATED PHENCYCLIDINE METABOLITES IN R H E S U S MONKEYS
نویسنده
چکیده
R.E. SOLOMON, S. HERLING and J.H. WOODS, Discriminative stimulus effects of monohydroxylated phencyclidine metabolites in rhesus monkeys, European J. Pharmacol. 82 (1982) 233-237. Rhesus monkeys were trained to discriminate saline from an injection of ketamine. In tests of stimulus generalization, phencyclidine (PCP) produced dose-related ketamine-appropriate responding in each monkey. Two monohydroxylated PCP metabolites also produced ketamine-like discriminative effects, although only at considerably higher doses than did PCP. A third monohydroxylated PCP metabolite produced only sham-appropriate responding. The results suggest that these PCP metabolites contribute little to the behavioral actions of PCP in the monkey.
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